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Mastodon: AboutGet the appKeyboard shortcutsView source codev4.4.0-nightly.2025-04-15

#structuralbiology

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Public
Enabla

What determines the folding and stability of protein structures? In his fourth lecture, Dr. Ali Hassanali from the Abdus Salam International Centre for Theoretical Physics (ICTP) explores the intricate world of protein secondary structures, focusing specifically on alpha helices and beta sheets. Dr. Hassanali explains how these structures are stabilized through a variety of interactions, including hydrogen bonding and electrostatic effects, and the critical role of dihedral angles as illustrated by the Ramachandran plot.

This lecture also highlights the essential contributions of cysteine in forming disulfide bonds, which enhance protein stability in challenging environments. By examining the interplay of molecular interactions, Dr. Hassanali provides insights into the architectural and functional significance of these secondary structures as well as their evolutionary adaptations.

🎥 Join us for this #OpenAccess lecture and engage in discussions with Dr. Hassanali himself and other members of the Enabla community: enabla.com/pub/606/about

The ICTP diploma program lecture "Molecular Architecture and Stability of Protein Secondary Structures: Alpha Helices to Beta Sheets" by Dr. Ali Hassanali is on Enabla in Open Access! Video, English, 1.4 hours
#Biophysics#Proteins#MolecularBiology
Public
Dave nλ=2dsinθ

New Presidential executive order on proteins:

All amino acids now to be right w̶i̶n̶g̶ handed.

Leftist amino acids to be outlawed.

(Also, Z-DNA is deemed to be Communist, and is prohibited.)

Trans- and cis- peptide bonds to be banned.

Non-binary amino acid Glycine to be banned.

Proline is not a real amino acid and will be banned immediately.

Phenylalanine looks and sounds a bit like Fentanyl, banned immediately.

@strucbio #StructuralBiology #PDB

Public
michael

26-Mar-2025
Remember #ebola?
Zooming in on the #structure of the still lethal #virus

eurekalert.org/news-releases/1 #science #structuralBiology #protein #capsid

EurekAlert!Remember ebola?Kyoto, Japan -- Six years before the start of the COVID-19 pandemic, an Ebola outbreak in West Africa had people fearing the possibility of a global outbreak. This was the first time many had ever heard of the virus, but since it was first identified in 1976, there have actually been more than 20 serious Ebola incidents. Thankfully, none of them had the global reach of the coronavirus. Ebola has not been eradicated, however. This deadly virus, which causes severe hemorrhagic fever in humans and has a fatality rate of about 50%, is still at large and could thus still cause a major outbreak, unless further research finds an effective solution. A major challenge lies in the virus' structure and regulatory mechanisms, which have remained largely unclear. In particular, scientists have long struggled to fully understand its nucleocapsid, the protein shell that plays an important role in genome replication and transcription.
Public *
Victoria Stuart 🇨🇦 🏳️‍⚧️

Molecular animations reveal DNA's unzipping mechanism: Implications for viral and cancer treatments
sciencedaily.com/releases/2025
le.ac.uk/news/2025/march/dna-h

* scientists captured 1st detailed 'molecular movie' showing DNA being unzipped at atomic level
* reveals how cells begin crucial process of copying their genetic material

Structural dynamics of DNA unwinding by a replicative helicase
nature.com/articles/s41586-025

ScienceDailyBreakthrough molecular movie reveals DNA's unzipping mechanism with implications for viral and cancer treatmentsScientists have captured the first detailed 'molecular movie' showing DNA being unzipped at the atomic level -- revealing how cells begin the crucial process of copying their genetic material.
#cancer#MolecularGenetics#StructuralBiology
Public
CSBJ

This study investigates the surprising limitations of AlphaFold 2 (AF2) in predicting protein structures—specifically its tendency to confidently predict β-solenoid folds for repeat proteins, even when the structures are unrealistic or unstable.

🔗 AlphaFold 2, but not AlphaFold 3, predicts confident but unrealistic β-solenoid structures for repeat proteins. DOI: doi.org/10.1016/j.csbj.2025.01

📚 CSBJ: csbj.org/

AlphaFold 2, but not AlphaFold 3, predicts confident but unrealistic β-solenoid structures for repeat proteins.
#AlphaFold#ProteinScience#StructuralBiology
Public *
François Ferron 🇪🇺 🔷️🔶️

There is an Associate Professor Position in #Bioinformatics with a Focus on #AI Applications in Integrated #StructuralBiology available in our Institute in Marseilles (France) @afmblab.bsky.social
@afmblab.bsky.social
@strucbio @bioinformatics

The successful candidate will create his/her own team for developing and implementing innovative AI-based approaches to address key challenges in structural biology, including but not limited to:
1. Designing synthetic proteins with novel or enhanced enzymatic properties.
2. Developing synthetic protein or biomolecule binders for therapeutic or biotechnological applications.
3. Performing molecular docking of small molecules on therapeutic targets.
4. Modelling macromolecular complexes in silico.

* Contact : For more information, please contact Juan Reguera, Unit Director, including a brief CV.
Formal applications should include:
• A detailed CV with a summary of past and present research and teaching activities.
• A short description of research project and implementation plan.
• A motivation letter.

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