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#optictectum

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My postdoc work at Isaac Bianco's lab is finally out on @eLife !
elifesciences.org/articles/783

Combining #lightsheet volumetric functional imaging and a spiking network simulation, we were able to show that a simple connectivity motif in the #zebrafish #optictectum explains multiple features in ongoing population dynamics, their impact on trial-to-trial variability, and trends in experience dependent behavior.

It is a neat example of how #networkdynamics can explain why neuronal and behavioural responses vary, or how past activity sets the ever-changing background for new input (that, in turn, will make its own long-lasting splash)

eLifeRecurrent network interactions explain tectal response variability and experience-dependent behaviorRecurrent interactions in the optic tectum underlie activity-dependent changes in network state that account for variability in sensory encoding and behavior.

Sierra Dixon, Bailey Calder &co show that valproic acid exposure leads to a delay in #zebrafish optic tectum #neurogenesis and #neuron specification:

journals.biologists.com/bio/ar

“Overall, our findings provide an initial characterisation of the deviances in development of the optic tectum in an Autism model”

Check out this interview with co-first author Bailey to find out more:

journals.biologists.com/bio/ar