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#toxicity

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Cytology and Genetics

Cytoprotective Impact of Chrysin (5,7-Dihydroxyflavone) upon Cyclophosphamide-Administered Experimental Animals - #chemotherapeuticagents #cyclophosphamide #chrysin #inflammation #toxicity #cancer #chemotherapy - link.springer.com/article/10.3

SpringerLinkCytoprotective Impact of Chrysin (5,7-Dihydroxyflavone) upon Cyclophosphamide-Administered Experimental Animals - Cytology and GeneticsAbstract Introduction. Chemotherapeutics are widely recognized for their adverse side-effects during anti-cancer regiments. One of the complementary approaches to circumvent this dilemma could be the exploitation of natural compounds, which could optimally counteract the cellular damages during chemotherapy. The present study ventures to evaluate the natural flavonoid, chrysin (5,7-dihydroxyflavone) for its therapeutic immunomodulatory properties along with the chemotherapeutic drug, cyclophosphamide (CP). Methods. Male Wistar albino rats were utilized for this study. Assays were conducted for acute toxicity, Hemolysis, Phagocytosis, Natural Killer (NK) cell cytotoxicity, and oxidative stress. RT-PCR, ELISA and Western Blot were performed to assess the expression of inflammatory markers. Results. Assay results such as Phagocytosis Index (0.009 ± 0.001), NK cell cytotoxicity (61.10 ± 4.99%), expression of Perforin (0.45 ± 0.05 fold) and Granzyme (0.86 ± 0.01 fold), hepatic antioxidative enzymes GSH (27.75 ± 1.54 μg/mg ), SOD (7.10 ± 0.35 U/mg ) and CAT (249.06 ± 31.30 μM/min/mg) and splenic hepatic antioxidative enzymes GSH (20.88 ± 0.74 μg/mg), SOD (7.10 ± 0.35 U/mg) and CAT (249.06 ± 31.30 μM/min/mg) among the CP-treated groups were compared with those for the CP+chrysin treated groups which were evaluated to be significantly increased with values of 0.016 ± 0.001, 82.73 ± 2.87%, 0.77 ± 0.08 fold, 1.11 ± 0.02 fold, 47.60 ± 3.02 μg/mg, 08.97 ± 0.42 U/mg, 467.19 ± 15.92 μM/Min/mg, 29.02 ± 1.59 μg/mg, 5.17 ± 0.94 U/mg, 310.29 ± 9.1330 μM/Min/mg, respectively. Histopathological examination indicated that CP+chrysin treated groups could recover from cellular damage triggered during the CP treatment. Conclusion. Results indicate the cytoprotective role of chrysin, which in turn, could be reliably administered as a complementary therapy along with CP during chemotherapy.
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Kevin Karhan :verified:

@centopus personally, I see @AsahiLinux as a "canary" project in that regard.

@linuxfoundation and @torvalds need to enshure that toxicity and neighsayers are toned down way harder, cuz bullying people like #marcan into quitting isn't gonna help anyone and will only damage #Linux by making it look like the "#Neckbeard" #TechBro shitshow that #Lunduke, RMS et. al. stan for...

  • I literally know a shitload of trans, non-binary or just non-#WHCM [white hetero/cis (binary) male] persons who refuse to even consider upstreaming or contributing to #Linux, #GNU or any #FLOSS projects at all due to the sheer #toxicity observed externally.

And that is a problem even if we don't care about #diversity, #equity and #inclusiom but merely the #survival of said #OpenSource projects!

  • Cuz why would I (or anyone else) want to work with/on/for a company/project that'll get me (deservedly [!!!]) side-eyed at best if not unfriended by the few people I care about personally?
marcan.stResigning as Asahi Linux project lead
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Impish4249

@jeffjarvis

#captainobvious there 'splaining for #Trump.

I'm editing this to reflect the person I want to be.

Note: I came here to get away from #toxicity like criticizing private people who we really don't know. I feel completely comfortable criticizing Trump directly. I also know some people who did vote for him who are quite intelligent, though I do think they are horribly misguided.

This morning I was the #toxic one and to my fedifriends I apologize.

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