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#immune

1 post1 participant0 posts today
Public
Cytology and Genetics

A Pan-Cancer Analysis of Ferroptosis-Related Gene Arachidonic Acid 15-Lipoxygenase-1 (ALOX15): Its Prognostic and Immunotherapeutic Values - #ferroptosis #bioinformatics #prognosis #pancancer #ALOX15 #biologicalfunctions #immune - link.springer.com/article/10.3

SpringerLinkA Pan-Cancer Analysis of Ferroptosis-Related Gene Arachidonic Acid 15-Lipoxygenase-1 (ALOX15): Its Prognostic and Immunotherapeutic Values - Cytology and GeneticsAbstract Background. Emerging research has identified ferroptosis as a novel form of programmed cell death, and Arachidonic acid 15-lipoxygenase-1 (ALOX15) stands out as a pivotal gene in mediating this process. Nonetheless, the role of ALOX15 in human tumors remains elusive. Methods. We utilized TIMER 2.0 to investigate the differential expression profiles of ALOX15 between pan-cancer and normal tissues. Further data from the TCGA, GEPIA, UALCAN, HPA, and CPTAC databases were analyzed to verify the levels of mRNA, protein expression, and promoter methylation across various cancer types. The survival prognosis, clinical features, and genetic alterations of ALOX15 were also evaluated. GO/KEGG enrichment analyses and single-cell transcriptome sequencing were employed for functional enrichment analysis. The gene mutation of ALOX15 and its prognostic value were analyzed using the cBioPortal platform. Finally, the relationship between ALOX15 and immune cell infiltration, Immune Checkpoints (ICKs), genomic instability, and drug sensitivity was further explored using GSCA. Results. Our findings revealed that the transcription and protein expression of ALOX15 were significantly reduced in HNSC, LUAD, LUSC, SKCM, KICH, and THCA, while they were up-regulated in ESCA, LIHC, PRAD, and UCEC. Notably, the expression of ALOX15 had prognostic value for certain cancers, including LUAD, LUSC, LIHC, KIRC, HNSC, THCA, and LGG. Additionally, ALOX15 expression was markedly correlated with clinical characteristics, immune cell infiltration, ICKs, genomic instability, and antitumor drug sensitivity in various tumors. Gene mutations of ALOX15 and their prognostic value were discovered in pan-cancers. Furthermore, GO/KEGG analysis and single-cell transcriptome sequencing indicated that ALOX15 was significantly associated with cancer-related pathways. Conclusion. Our comprehensive pan-cancer analysis shed light on the role and significance of ALOX15, suggesting its potential as a prognostic and immunotherapeutic marker for pan-cancer. These findings may provide new directions and evidence for cancer therapeutics.
Public
Daniel Dvorkin

There are a number of panicky Facebook posts, to which I will not link, going around about the "shocking" discovery that #mRNA #vaccines cross the #placental barrier. Which really shouldn't be a surprise to anyone, but #antivaxers gonna #antivax.

Okay, the discovery is real enough. Here's a direct link: sciencedirect.com/science/arti Click the "View PDF" button at the top, just above the journal title, to read the full article. Note that this is a pre-print version, meaning there may be some typos and such, but nothing that's likely to change the results.

The problem is ... well, there's no problem here! #Maternal #immunity, however acquired, is routinely passed on to #fetuses: we're all born with #immune systems primed to deal with whatever #diseases our mothers have encountered, and that's a *good thing*.

Of course antivaxers who freak out about any occurrence of the abbreviation "mRNA," like the same people often freak out about the word "pronoun" or the "cis-" and "trans-" prefixes, think this is somehow evil.

It's not. It means *fewer dead kids*. These people would literally rather kill their children than learn anything that contradicts their ideology.

Public
Perceptions Today

New discovery could help protect against #influenza

Preclinical trial uncovers how beta-glucan, found in all #fungi, can ‘reprogram’ #immune cells to prevent #lung inflammation

A component found in all fungi may provide a shield against #flu-related lung damage, according to a new study.

A team of scientists led by #MaziarDivangahi, a Professor in #McGill’s Faculty of Medicine and Health Sciences and Senior Scientist at the Research Institute of the McGill #University Health Centre, demonstrated that beta-glucan, administered to #mice before their exposure to influenza, can reduce lung damage, improve lung function and lower the risk of #illness and #death.

mcgill.ca/newsroom/channels/ne

#medicine
#copd
#breathing
#mcgilluniversity
#breakthrough
#mushrooms 

Public
Scientific Frontline

People who watch videos of #sneezing or sick people show increased activity in #brain regions that represent an interface between the brain and the #immune system and react to potential dangers. At the same time, the concentration of #antibodies in their saliva increases.
#Biology #Neuroscience #sflorg
sflorg.com/2025/02/bio02042501

www.sflorg.comVideos with Cold Symptoms Activate Brain Regions and Trigger Immune Response Study on Brain Activity and Antibody Concentration
Continued thread
Public
DoomsdaysCW

Still reeling from #PFAS spill, #BrunswickMaine residents push back on plans for #sludge treatment plant

by AnnMarie Hilton, Tue, January 28, 2025

"Brunswick resident Sandra Carslick said she and her neighbors have been living in a 'bad dream' for the five months since 1,600 gallons of toxic foam spilled so-called forever chemicals at the already contaminated former Naval Air Station nearby.

"At a Brunswick Town Council meeting on Monday night, Carslick said that bad dream could soon become residents’ 'worst nightmare,' if the town reopens a processing site for chemical-laden [#Biosolids] sludge from sewer treatment plants across Maine, and potentially beyond.

"The residents were responding to plans from Delaware-based #ViridiEnergy to update and expand #BrunswickLanding’s anaerobic digester, which converts sewage sludge — also referred to as #biosolids — into renewable natural gas and byproducts that get sent to landfills.

"During Monday’s presentation to the town council, company representatives explained how the facility would work and what local residents could expect. Several councilors said they would like to see additional data before deciding, but some already expressed concerns that the project isn’t right for Brunswick, particularly at this time. Members of the public also spoke for more than an hour, overwhelmingly concerned about the project and its potential to bring more #HarmfulChemicals into the area.
"The town is still dealing with the accidental discharge last summer of #firefighting foam containing #perfluoroalkyl and #polyfluoroalkyl substances, also known as #PFAS, at a hangar at #BrunswickExecutiveAirport, which is also situated at Brunswick Landing.

"The spill has prompted environmental and public health concerns over the PFAS, which have been linked to serious long-term health problems including #cancer, weakened #immune systems, developmental issues, and more. Since it started surveying and reviewing the material in the late 1980s, the U.S. Environmental Protection Agency [#EPA] has found more than 700 chemicals in sewage sludge, including PFAS.

"Chet Benham, a senior advisor and one of the founders of Viridi, tried to address those concerns during the meeting, telling residents the facility will operate according to all state and local requirements. He said there are protocols to prevent spills of the sludge that will move through the closed-loop facility.

"'We feel really, really good about it,' Benham said. 'We wouldn’t be standing here before you if we didn’t.' [Typical #Greenwashing #Bullshit]

"According to Viridi’s plan, the facility would take in about 85,000 tons of biosolids per year, which would be processed into renewable natural gas that would feed into Maine Natural Gas. About 10,000 tons of solid material byproduct would be sent from the plant to the #JuniperRidgeLandfill in Old Town. Over the course of the discussion, it came to light that Viridi would also likely bring in sludge from outside of Maine in order to run their facility at full capacity."

Read more:
news.yahoo.com/news/still-reel
#WaterIsLife #PenobscotRiver #PenobscotNation #AndroscogginRiver #CascoBay

Yahoo News · Still reeling from PFAS spill, Brunswick residents push back on plans for sludge treatment plantBy AnnMarie Hilton
Public
Daniel Hoffmann 🥬

Very simple, completely unexpected: human #tumor cells steal working #mitochondria (= cellular power plants) from #immune cells, & return defective mitochondria, poisoning the immune cells. Unclear how widespread mechanism is, still remarkable.
nature.com/articles/d41586-025

www.nature.comMitochondrial swap from cancer to immune cells thwarts anti-tumour defencesBidirectional transfer of mitochondria between cancer and immune cells.
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